Dynamic expression of CX36 protein in kainic acid kindling induced epilepsy
نویسندگان
چکیده
منابع مشابه
Dynamic Expression of CX36 Protein in Kainic Acid Kindling induced Epilepsy
Connexin (Cx) 36 is known to be a component of gap junctions, and has been suggested to play an important role in epilepsy. In order to determine dynamic changes of Cx36 protein expression in epilepsy and investigate the role of Cx36 in electroencephalographic activity and pathogenesis, we utilized kainic acid (KA) to induce epileptogenesis. We found that epileptic discharges began 71.8 ± 23.7 ...
متن کاملThe protective effect of carvacrol on kainic acid-induced model of temporal lobe epilepsy in male rat
Background and Objective: Temporal lobe epilepsy (TLE) is a chronic neurological disorder with spontaneous recurrent seizures and abnormal intracranial waves. Since the role of oxidative stress in the occurrence of epilepsy is inevitable, it seems that the use of antioxidants can prevent some of the complications resulting from this disease. This study was designed to assess the protective effe...
متن کاملantiepileptic effect of vitamin e on kainic acid-induced temporal lobe epilepsy in rats
background epilepsy is a chronic neurological disease with the prevalence of around one percent. despite the introductions of several anti-epileptic drugs, around 1/3 of epileptic patients are resistant to the anti-epileptic medications. objectives considering the evidence regarding the anti-oxidant action of vitamin e and its beneficiary effect in the treatment of epilepsy, we investigated the...
متن کاملBlocking of rat hippocampal Cx36 by quinine accelerates kindling epileptogenesis
There are abundant studies indicating that blocking gap junctions (GJs) containing connexin 36 (Cx36) inhibit seizures. However, recent evidences demonstrate proconvulsant effect of such intervention. Electrical coupling between GABAergic interneurons in CA1 region of hippocampus is mediated through Cx36 GJs. We investigated effect of quinine, a specific blocker of Cx36, on the seizure severity...
متن کاملThe Effects of Kainic Acid-Induced Seizure on Gene Expression of Brain Neurotransmitter Receptors in Mice Using RT2 PCR Array
Introduction: Kainic acid (KA) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (TLE). According to different studies, the expression of a number of genes are altered in the adult rat hippocampus after status epilepticus (SE) induced by KA. This study aimed to quantitatively evaluate changes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Translational Neuroscience
سال: 2017
ISSN: 2081-6936
DOI: 10.1515/tnsci-2017-0007